Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
8
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.
As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
Most Useful Reviews
7.5
Pregnancy support
Folic acid is excellent for restoring immunity and enhancing the heart's function and blood vessels. I use it as per my doctor's advice for pregnancy planning. A pack of 150 is reasonably priced, and NOW is a preferred brand. It’s a beneficial supplement for any woman.
Read More
7
Heart function enhanced
Folic acid improves immunity, supports heart and blood vessel function, and aids in the formation of blood cells (erythrocytes) during iron deficiencies.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.2
- All Researches
9
Maternal folic acid reduces CHD risk
We explored how maternal folic acid supplementation relates to congenital heart disease (CHD) in children. Through a case-control study involving 595 children with CHD and 605 healthy controls, we found that mothers taking folic acid significantly reduced the risk of CHD and its subtypes. Notably, variations in the MTRR gene among offspring were linked to higher CHD risks, but maternal folic acid appeared to mitigate some of this risk. While results are promising, further research with larger samples is essential to fully understand these findings.
Read More
9
We explored the potential benefits of folic acid in treating dangerous heart rhythm problems linked to TANGO2-deficiency disorder (TDD). By creating patient-derived heart cell models, we observed that high doses of folate significantly reduced these arrhythmias. Additionally, clinical studies indicated that taking multivitamins, particularly those rich in B complex, lowered the chance of heart crises in TDD patients. Together, these findings suggest that B vitamins, including folate, could be vital in managing severe heart complications associated with this rare genetic disorder.
Read More
9
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
8
We investigated whether folic acid treatment could help lower heart disease risk related to elevated homocysteine levels. The study highlighted that hyperhomocysteinemia is a significant independent risk factor for atherosclerosis, which can contribute to serious cardiovascular events. While folic acid, alongside other B vitamins, effectively reduces homocysteine levels, it does not appear to significantly improve heart disease outcomes on its own. Thus, while folic acid plays a role in managing homocysteine, its impact on preventing heart disease is less clear.
Read More
8
We explored how folic acid affects patients with coronary heart disease (CHD) and hypertension, particularly considering the MTHFR C677T gene. The study included 540 patients who received either folic acid treatment alongside enalapril or standard care.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
While both folic acid and non-folic acid groups showed lower rates of cardiovascular events compared to the control group, the results suggested folic acid may enhance patient outcomes in those with H-type hypertension. Overall, folic acid seems to support better blood pressure management and improves prognosis among high-risk patients, highlighting the importance of genetic screening in treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Pregnancy support
Folic acid is excellent for restoring immunity and enhancing the heart's function and blood vessels. I use it as per my doctor's advice for pregnancy planning. A pack of 150 is reasonably priced, and NOW is a preferred brand. It’s a beneficial supplement for any woman.
Read More
7
Heart function enhanced
Folic acid improves immunity, supports heart and blood vessel function, and aids in the formation of blood cells (erythrocytes) during iron deficiencies.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. doi:10.1186/s12940-024-01150-7
- Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. doi:10.1186/s41043-024-00699-w
- Prasad K. Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment. Int J Angiol. 2024;33:262. doi:10.1055/s-0044-1788280
- Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. doi:10.14715/cmb/2024.70.9.20
- Ruan XR, Sun MT, Wei JH, Luo MJ, Liu HJ, et al. [Maternal gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects]. Zhongguo Dang Dai Er Ke Za Zhi. 2024;26:899. doi:10.7499/j.issn.1008-8830.2403067
- Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. doi:10.1172/jci.insight.171005
- Hua Y, He Z, Ni Y, Sun L, Wang R, et al. Silk fibroin and hydroxypropyl cellulose composite injectable hydrogel-containing extracellular vesicles for myocardial infarction repair. Biomed Phys Eng Express. 2024;10. doi:10.1088/2057-1976/ad40b2
- Liu L, Zhang X, Geng HR, Qiao YN, Gui YH, et al. High paternal homocysteine causes ventricular septal defects in mouse offspring. iScience. 2024;27:109447. doi:10.1016/j.isci.2024.109447
- Sobot T, Bajic Z, Skrbic R, Uletilovic S, Mandic-Kovacevic N, et al. Effect of folic acid on isoprenaline-induced myocardial injury in rats. Physiol Int. 2024;111:80. doi:10.1556/2060.2023.00291
- Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, et al. MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults. Int J Epidemiol. 2023;52:1862. doi:10.1093/ije/dyad147
- Chen L, Yang T, Wang T, Sun M, Qin J. Relationships between Maternal Folic Acid Supplementation and Gene Polymorphisms in Patients with Non-Chromosomal Congenital Heart Disease: A Hospital-Based Case-Control Study in China. Nutrients. 2023;15. doi:10.3390/nu15204478
- Ju DT, Huang RS, Tsai BC, Su YC, Chiu PL, et al. Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways. Neurotox Res. 2023;41:648. doi:10.1007/s12640-023-00666-z
- Dkhillon D, Samogulova A, Kolobov B. B Vitamins as Adjunctive Treatment for Chronic Heart Failure. Cardiovasc Hematol Disord Drug Targets. 2023;23:64. doi:10.2174/1871529X23666230719090419
- Webber DM, Li M, MacLeod SL, Tang X, Levy JW, et al. Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study. Genes (Basel). 2023;14. doi:10.3390/genes14010180
- Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. doi:10.1001/jamanetworkopen.2024.38747
- Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. doi:10.1016/j.ymgmr.2024.101089
- DomĂnguez-LĂłpez I, Kovatcheva M, Casas R, Toledo E, FitĂł M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. doi:10.1002/jsfa.12976
- Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. doi:10.1016/j.biopha.2023.114761
- Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. doi:10.2174/1573403X19666230209111854
